Totally revamped, no more class selection at the start of the game, every skill you level contributes to your overall level. And each time you level you get extra health plus the ability to get either more health, magicka or stamina.
Each level also brings you perks. Cool abilities I guess like in Fallout 3.
Also, the leveling was moved from 1-25 or something like that to 1-50, but 50 is soft-capped, you just advance really slow after that.
Mysticism is gone.
18 skills, down from 21 on Oblivion, and 27 on Morrowind.
Tries to accommodate players who want to specialize in a certain profession (like mage or thief), while at the same time giving room for players who like to do plenty of everything. They want to keep a special care so that this feels good, not prone to cheating and organic.
200 years after Oblivion. Set in Skyrim, a region north of the imperial city, where the Nords live.
The dragons are returning, as it was prophetized. You are gonna be trying to stop the wicked dragon god. You are a dragonborn, a dragon hunter. Your mentor is one of the last blade, voiced by some old dude from Shutter Island and Minority Report.
Also, there is a civil war, since the king is dead.
Enemies include were-yeti's, giant spider, dragons and other cool creatures.
They want to make it more dynamic and tactical. You have to assign each hand with a function I think, either magic, 2 weapons, a weapon and a shield, etc.
You can also waste stamina by sprinting, allowing you to get access to tactical positions.
Emphasis on really improving the combat this time around.
They are also putting care on how each weapon feel on your hand.
Quests are much more dynamic now. The quests are now more determined by how you build your character, individual actions and overall much more dynamic. Examples provided: If you are more of a magic user, some other mage may approach you who may not have had if you were just a melee character. Or if you killed some dude who owned a store that was gonna give you a quest, his sister would inherit the store, but she may resent you before giving you the quest. Also, if you drop a weapon in the street instead of selling it, it may just dissapear, some kid may get it and give it back to you, which would lead to a series of stuff, or some dudes may fight over who gets it.
Also, it said that the quests you are given would be modified by how you have played (I guess like scaling the quests). For example, the location of a rescue mission would be determined by which location you have visited (it will try to give you a dungeon you haven't been in) and I guess also giving you appropriate enemies to your level.
Third person view has been improved
5 massive cities, more variation in caves and underground stuff.