Robby pointed out how Love Hina was eerily similar with the penultimate chapter. And Negima is probably going to end the same way. It'll be harder since there is 30+ students and all the otherm inor characters to cram into 19-20 pages (since I think Akamatsu isn't going to add that many extra pages IIRC), but I think the question of "who did Negi choose" along with some open-ended bright future stuff will happen.
It's odd that Akamatsu seemed to be set on ending the series but left so many more open ended questions in his "last arc". I think that was why so many here thought it was continuing even though there were some end game vibes coming from the magic world arc. It's an odd choice, but maybe he meant the series to be open ended to an extent.
Speaking of the author, from the interview on page 95, Akamatsu seems tired of writing the manga. I'm just noting if that's the case, it's impressive as a writer that he kept the quality up, or at least kept it to the point where the people on this thread were satisfied through and through (well, last few chapters aside, and even that's a maybe)
And if chapter 353 is any indication, an unknown future holds infinite possibilities. And since there are parallel dimensions, I could imagine the fanbase can just write their own ending to the series, saying it is happening in X dimension. I mean, there's no reason why the sleeping Asuna in this world can't be sent to another dimension like the awake Asuna and have the whole process repeat itself in other dimensions etc...